Table 1.
Enriched variations
| Label | Phenotype | N | Ess. genes | Paralog | Frame shifts | Stop codon | Copy no. |
|---|---|---|---|---|---|---|---|
| Mel_R | Melibiose 2% Rate | 33 | 0 | 2.06* | 0.25 | 1.23 | 4.41* |
| Mel_E | Melibiose 2% Efficiency | 40 | 0 | 0.78 | 0.20 | 1.37 | 3.59 |
| Cup_R | Cupper chloride 0.375 mM Rate | 60 | 0.16 | 2.56***••• | 0.15 | 1.63 | 6.42***••• |
| Cup_E | Cupper chloride 0.375 mM Efficiency | 14 | 0 | 2.19 | 0.11 | 3.36* | 11.42**• |
| NaC1_R | NaCl 0.85 M Rate | 58 | 0.16 | 2.91***••• | 0.05 | 1.16 | 8.25***••• |
| NaC2_R | NaCl 1.25 M Rate | 47 | 0.31 | 1.12 | 0.13 | 1.46 | 0 |
| NaC1_E | NaCl 0.85 M Efficiency | 47 | 0.01 | 2.34***•• | 0.13 | 1.46 | 12.70***••• |
| NaC2_E | NaCl 1.25 M Efficiency | 43 | 0.11 | 1.25 | 0.14 | 0.92 | 3.33 |
| Mal_R | Maltose 2% Rate | 59 | 0.51 | 2.05**•• | 0.19 | 1.39 | 11.50***••• |
| Mal_E | Maltose 2% Efficiency | 45 | 0.32 | 1.37 | 0.21 | 0.87 | 13.37***••• |
| Gal_R | Galactose 2% Rate | 30 | 0 | 1.67 | 0 | 0.88 | 22.11***••• |
| Gal_E | Galactose 2% Efficiency | 49 | 0.19 | 2.67***••• | 0.27 | 1.40 | 22.11***••• |
| Hea1_R | Heat 37°C Rate | 33 | 0 | 2.06*• | 0.09 | 2.20* | 9.65***••• |
| Hea2_R | Heat 40°C Rate | 44 | 0 | 2.06**• | 0.07 | 1.23 | 13.73***••• |
| Hea1_E | Heat 37°C Efficiency | 44 | 0.11 | 1.21 | 0.26 | 1.58 | 1.568 |
| Hea2_E | Heat 40°C Efficiency | 49 | 0.40 | 1.78* | 0.12 | 1.72 | 9.99***••• |
| Sod1_R | Sodium arsenite oxide 3.5 mM Rate | 48 | 0 | 5.58***••• | 0.13 | 2.11*• | 12.38***••• |
| Sod2_R | Sodium arsenite oxide 5 mM Rate | 33 | 0.29 | 3.15***•• | 0.09 | 2.20* | 2.11 |
| Sod1_E | Sodium arsenite oxide 3.5 mM Efficiency | 44 | 0.22 | 1.83* | 0.18 | 1.95 | 13.73***••• |
| Sod2_E | Sodium arsenite oxide 5 mM Efficiency | 43 | 0 | 3.62***••• | 0.14 | 2.40**• | 3.33 |
Certain types of variations that are over-represented among the N influential genes for all phenotypes. The statistics are odds-ratios indicating potential enrichment of certain gene categories among the influential genes. The categories are: Essential genes, genes with known paralogs, genes with known frame shift variation, genes with known stop codon variation and genes with known copy number variations in yeast. Significance at 10% is marked with *, 5% is marked with ** and 1% is marked with ***. The corresponding significance based on adjusted p-values controlling the false discovery rate (q-values) are marked with •, •• and •••, respectively.