Table 1.
Univariate Logistic Regression Analysis for Hemorrhagic Transformation (HT)
| Variable | No HT (n = 62) | HT (n = 22) | OR | P |
|---|---|---|---|---|
| Female, no. (%) | 35 (56.5) | 9 (40.9) | .534 | .213 |
| Age (years), median (IQR) | 73 (65-82) | 64 (54-80) | .979 | .199 |
| Systolic BP (mm Hg), mean (SD) | 144 (28.1) | 147 (27.4) | 1.004 | .682 |
| Glucose (mmol/L), mean (SD) | 6.9 (2.1) | 8.4 (3.5) | 1.011 | .035 |
| Platelets (×103/μL), mean (SD) | 259 (100) | 244 (77.6) | .998 | .508 |
| Diabetes mellitus, no. (%) | 11 (17.7) | 4 (18.2) | 1.030 | .963 |
| Hypertension, no. (%) | 37 (59.7) | 10 (45.5) | .563 | .251 |
| Hyperlipidemia, no. (%) | 25 (40.3) | 6 (27.3) | .555 | .279 |
| Atrial fibrillation, no. (%) | 23 (37.1) | 9 (40.9) | 1.174 | .752 |
| Smoker, no. (%) | 16 (25.8) | 5 (22.7) | .846 | .775 |
| NIHSS score, median (IQR) | 12 (8-15) | 15.5 (11-19) | 1.149 | .006 |
| Proximal occlusion, no. (%) | 25 (40.3) | 16 (72.7) | 3.947 | .012 |
| Collateral score, median (IQR) | 2 (2-3) | 2 (1-3) | .440 | .008 |
| ASPECTS, median (IQR) | 7 (6-8) | 6 (5-7) | .731 | .021 |
| CBF (mL/100g/min), mean (SD) | 4.7 (4.2) | 2.1 (1.6) | .675 | .009 |
| CBV (mL/100g), mean (SD)* | .8 (.4) | .3 (.2) | .003 | <.001 |
| Time to CT (hours), mean (SD) | 3.8 (2.0) | 4.0 (1.8) | 1.026 | .824 |
| IV or IA tPA, no. (%) | 31 (50.0) | 8 (36.4) | .571 | .273 |
*
Significant at < .05 on multivariate analysis, ASPECTS = Alberta Stroke Program Early CT Score; BP = blood pressure; CBF = minimal cerebral blood flow; CBV = minimal cerebral blood volume; IA = intraarterial; IQR = interquartile range; IV tPA = intravenous tissue plasminogen activator; NIHSS = National Institutes of Health stroke scale; OR = odds-ratio; SD = standard deviation.