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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Exp Mol Pathol. 2011 May 27;91(2):496–501. doi: 10.1016/j.yexmp.2011.05.006

Figure 5. Schematic representation of potential mechanism by which EGF could increase the expression of LRF in prostate cells.

Figure 5

EGF binds to its receptor and activates a signaling cascade to transcribe LRF. LRF binds to the p65 subunit of NF-κ which activates other signaling mechanisms leading to the aberrant proliferation of the prostate cells.