Figure 1.

The final pharmacokinetic–pharmacodynamic interaction model and illustration of pharmacokinetic and pharmacodynamic response profiles. Abbreviations: CLr, rocuronium clearance; CLs, sugammadex clearance; k₁, rate constant of association between sugammadex and rocuronium; k₂, rate constant of dissociation; k_el,roc, rate of elimination of rocuronium; k_el,sug, rate of elimination of sugammadex; k_eo, distribution rate constant between central and effect compartments; k_s, rate constant; Q2r, intercompartment clearance of rocuronium from the central to the peripheral compartment; Q2s, intercompartment clearance of sugammadex from the central to the peripheral compartment; V1r, volume of distribution of rocuronium in the central compartment; V1s, volume of distribution of sugammadex in the central compartment; V2r, volume of distribution of rocuronium in the effect compartment; and V2s, volume of distribution of sugammadex in the effect compartment. Rocuronium plasma, free (); Rocuronium plasma, free + complex (); Rocuronium effect compartment, free (); sugammadex plasma, free + complex (); T₄/T₁ twitch ratio ()