Figure 2.
Observed and population-predicted sugammadex plasma concentrations for adult, paediatric, elderly and renally impaired populations conditioned on sugammadex dose (one subject treated with sugammadex 0.1 mg kg−1 is not shown). Red lines represent population predictions for three typical subjects reflecting variability in renal function for adults or age for paediatric subjects. Demographic data from patients with lowest, median and highest creatinine clearance, or age in case of the paediatric population, within the depicted populations were used to define typical subjects; all data are shown up to 10 h postdose