Figure 6.

Posterior predictive check of the pharmacokinetic–pharmacodynamic model for sugammadex mediated reversal times (time to train-of-four ratio of 0.9 [TOF90] and 0.7 [TOF70]) of rocuronium-induced neuromuscular blockade, observed (OBS) and predicted (PRED and IPRED) reversal times. Red dashed lines represent loess smooth curve. Prediction error (OBS-PRED) for population-predicted TOF90 time: 0.25 min; Prediction error (OBS-IPRED) for individual predicted TOF90 time: 0.5 min; Prediction error (OBS-PRED) for population-predicted TOF70 time: 0 min; Prediction error (OBS-IPRED) for individual predicted TOF70 time: 0 min