Table 3.

Typical subjects used in simulations

Population	Infant 1 year	Child 7 years	Adolescent 15 years	Adult 40 years	Elderly 75 years
Bodyweight (kg)*	10.3	23.0	56.2	75	75
Height (cm)*	75.5	122	170	NA	NA
Stages of renal function†‡
Normal renal function	25.7	51.2	95.3	100	80
Mild renal impairment	12.9	25.6	47.6	50	50
Moderate renal impairment	7.72	15.3	28.6	30	30
Severe renal impairment	2.57	5.12	9.53	10	10

^*Age-matched bodyweight and height values for typical paediatric subjects were taken from growth curves [44].

^†Paediatric creatinine clearance (CL_CR) values were scaled on body surface area (BSA) as calculated by Dubois and Dubois [39], as follows: CL_CR = 100 × (BSA_paed/BSA_adult).

^‡CL_CR (ml min⁻¹) limits were used to define stages of renal function.