Table 6.
Simulated reversal times [time to train-of-four ratio to 0.9 (TOF90), median and 90% confidence interval] for typical non-Asian subjects with normal renal function
| Reversal time to TOF90 (min) | ||||||
|---|---|---|---|---|---|---|
| Anaesthesia | No sevoflurane | Sevoflurane | ||||
| Scenario | Infant 1 year | Child 7 years | Adolescent 15 years | Adult 40 years | Elderly 75 years | Adult 40 years |
| Reversal 3 min after rocuronium | 0.5 | 0.8 | 0.8 | 0.8 | 0.8 | 0.8 |
| 16 mg kg−1 sugammadex at 3 min after 1.2 mg kg−1 rocuronium | 0.3–2.5 | 0.3–2.8 | 0.3–3.3 | 0.3–3.3 | 0.3–3.5 | 0.3–3.5 |
| Deep blockade reversal | 0.8 | 1.0 | 1.3 | 1.5 | 1.8 | 1.8 |
| 4 mg kg−1 sugammadex at 15 min after 0.6 mg kg−1 rocuronium | 0.3–3.3 | 0.3–4.3 | 0.3–5.5 | 0.5–6.0 | 0.5–6.5 | 0.5–11 |
| Moderate blockade reversal | 1.0 | 1.3 | 1.3 | 1.4 | 1.5 | 1.6 |
| 2 mg kg−1 sugammadex at reappearance of T2 | 0.3–3.8 | 0.5–4.8 | 0.5–5.5 | 0.5–5.5 | 0.5–6.0 | 0.5–8.5 |