Table 2.
Summary of main study results
| Mean ± SD | ||||
|---|---|---|---|---|
| Day 0 | Day 30 | Day 60 | Day 90 | |
| Weight (lb) | ||||
| Arm A | 195 (± 39) | 195 (± 39) | 196 (± 38) | 195 (± 37) |
| Arm B | 191 (± 32) | 191 (± 32) | 191 (± 31) | 191 (± 32) |
| Systolic BP (mm Hg) | ||||
| Arm A | 134 (± 14) | 130 (± 14) | 131 (± 16) | 132 (± 17) |
| Arm B | 135 (± 16) | 132 (± 15) | 132 (± 16) | 133 (± 17) |
| Diastolic BP (mm Hg) | ||||
| Arm A | 82 (± 8) | 80 (± 8) | 78 (± 9) | 79 (± 8) |
| Arm B | 80 (± 10) | 77 (± 10) | 78 (± 8) | 78 (± 9) |
| Heart rate (beats min−1) | ||||
| Arm A | 67 (± 8) | 65 (± 8) | 67 (± 9) | 67 (± 7) |
| Arm B | 70 (± 9) | 68 (± 8) | 69 (± 9) | 69 (± 8) |
| Serum atorvastatin* (ng ml−1) | ||||
| Arm A | 9.4 (5.3–21.1) | 11.9 (7.7–26.5) | 11.2 (7.3–19.7) | 11.2 (7.5–21.2) |
| Arm B | 10.1 (5.2–17.3) | 8.1 (3.7–12.0) | 8.9 (4.2–18.0) | 7.5 (3.8–11.8) |
| Cholesterol (mg 100 ml−1) | ||||
| Arm A | 159 (± 20) | 157 (± 26) | 158 (± 27) | 155 (± 26) |
| Arm B | 167 (± 31) | 169 (± 28) | 170 (± 33) | 173 (± 32) |
| Tryglycerides (mg 100 ml−1) | ||||
| Arm A | 123 (± 49) | 132 (± 56) | 142 (± 68) | 137 (± 60) |
| Arm B | 128 (± 72) | 143 (± 98) | 154 (± 116) | 156 (± 104) |
| HDL (mg 100 ml−1) | ||||
| Arm A | 46 (± 13) | 44 (± 13) | 44 (± 12) | 44 (± 12) |
| Arm B | 46 (± 11) | 44 (± 9) | 43 (± 10) | 44 (± 10) |
| LDL (mg 100 ml−1) | ||||
| Arm A | 88 (± 17) | 86 (± 17) | 86 (± 17) | 84 (± 17) |
| Arm B | 93 (± 21) | 97 (± 20) | 98 (± 21) | 101 (± 23) |
| LDL : HDL ratio | ||||
| Arm A | 3.57 (± 0.74) | 3.69 (± 0.76) | 3.73 (± 0.82) | 3.67 (± 0.78) |
| Arm B | 3.71 (± 0.84) | 3.95 (± 0.88) | 4.12 (± 0.94) | 4.06 (± 0.93) |
| ALT* (u l−1) | ||||
| Arm A | 31 (23–39) | 32 (23–42) | 31 (23–39) | 31 (24–38) |
| Arm B | 30 (24–37) | 31 (26–36) | 30 (24–36) | 29 (24–34) |
| AST* (u l−1) | ||||
| Arm A | 26 (20–31) | 26 (21–31) | 25 (18–33) | 26 (22–30) |
| Arm B | 25 (20–31) | 27 (22–31) | 25 (21–29) | 25 (22–29) |
| CPK* (u l−1) | ||||
| Arm A | 90 (60–119) | 96 (62–130) | 92 (53–131) | 94 (60–128) |
| Arm B | 79 (40–119) | 89 (55–123) | 80 (53–106) | 84 (55–113) |
| Subjective ratings | ||||
| Physical well-being (PCS) | ||||
| Arm A | 47.0 (± 9.1) | 48.0 (± 9.5) | 47.9 (± 7.9) | 48.2 (± 8.0) |
| Arm B | 46.1 (± 9.7) | 47.4 (± 9.5) | 47.4 (± 9.7) | 46.7 (± 8.9) |
| Emotional well-being (MCS) | ||||
| Arm A | 55.5 (± 6.0) | 55.3 (± 6.3) | 57.4 (± 4.5) | 57.4 (± 4.3) |
| Arm B | 54.2 (± 7.2) | 54.5 (± 6.5) | 54.8 (± 6.0) | 54.9 (± 6.3) |
| Myalgia score | ||||
| Arm A | 3.83 (± 0.89) | 3.93 (± 1.02) | 3.65 (± 1.04) | 3.75 (± 0.94) |
| Arm B | 3.80 (± 1.00) | 3.79 (± 1.09) | 3.93 (± 0.92) | 3.81 (± 0.95) |
| Memory score | ||||
| Arm A | 4.20 (± 0.88) | 4.16 (± 0.96) | 4.33 (± 0.67) | 4.34 (± 0.68) |
| Arm B | 4.51 (± 0.63) | 4.50 (± 0.71) | 4.37 (± 0.74) | 4.40 (± 0.68) |
*
Median and interquartile range.