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. 2010 Dec 3;45(2):393–402. doi: 10.1165/rcmb.2010-0342OC

Figure 4.

Figure 4.

Ptch1 is required for the murine response to systemic LPS. (A) B6;129Ptch+/− mice show decreased morbidity (dashed line) compared with B6;129Ptch1+/+ mice (solid line) followed by systemic LPS challenge (n = 9 in each group). Curve comparison was performed using the Mantel-Cox log-rank test implemented in GraphPad Prism (P < 0.0001). (B) B6;129Ptch1+/− mice produce less serum TNF-α and IL-6 than wild-type control mice after systemic LPS treatment (n = 9 in each group). Two-tailed t test P < 0.07 (trend toward significance) for TNF-α and P < 0.05 (significant) for IL-6.