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. 2010 Dec 3;45(2):419–425. doi: 10.1165/rcmb.2010-0151OC

Figure 1.

Figure 1.

Chlorine gas (Cl2) exposure inhibits aortic vasodilation in response to acetylcholine. Rats were exposed to air (open squares) or Cl2 (400 ppm, 30 min). Aorta were isolated at 6 (closed triangles), 24 (closed circles), or 48 hours (open circles) thereafter, and vasoconstriction and vasodilation responses to phenylephrine (PE) (A) or acetycholine (Ach) (B), respectively, were determined. Data are means ± SEM for cumulative dose-dependent changes in tension. *P < 0.05 by two-way repeated measures ANOVA with Bonferroni post-test for 24 and 48 hours after Cl2 exposure relative to control (n = 3–12). (C and D) EC50 values for PE-dependent vasoconstriction and Ach-dependent vasodilation, respectively, in aorta isolated from rats 24 hours after exposure to different doses of Cl2 (0–400 ppm) for 30 minutes. Data show mean ± SEM. *P < 0.05 by one-way ANOVA with Bonferroni post-test relative to control (n = 5–11).