Figure 3. Dot-plot of breakpoints from Polg^D257A/D257A brain and heart (P1).

For each breakpoint, the position of the 5′ base (F) is plotted against the position of the 3′ base (R), equivalent to the blue and red frequencies respectively in Figures 2b and 2d. The frequency of each unique breakpoint is indicated by dot size with frequencies binned into nine equally sized bins from 1 ( ) to 119 ( ) occurrences in brain and six bins from 1 ( ) to 24 ( ) occurrences in heart. Genetic maps of mtDNA are aligned opposite each axis with detail as in Figure 2.