. Author manuscript; available in PMC: 2011 Dec 1.

Published in final edited form as: Cell Metab. 2010 Dec 1;12(6):675–682. doi: 10.1016/j.cmet.2010.11.012

Table 1. Overview of Mito-seq data.

SNV and indel data is corrected for differences in coverage using differences in minimum counts or assembly of partial data sets (parenthesis). Normalized read pair data and BLAST data refers to normalization of read pair frequencies to the ratio of total aligned read pairs within each assembly.

Subject information	Tissue	Brain	Brain	Brain	Heart	Heart	Brain
	Mouse ID	P1	W1	P1	W1	P2	W2
	Genotype	Polg^D257A/D257A	Polg^wt/wt	Polg^D257A/D257A	Polg^wt/wt	Polg^D257A/D257A	Polg^wt/wt
	Age (weeks)	44	48	44	48	27	12
SNV and indel data	Total SNPs	253 (514)	0	712 (1070)	0	100	15
	% identity vs brain P1	X	-	76	-	12	-
	% identity vs heart P1	84	-	X	-	8	-
	% identity vs brain P2	4	-	0	-	X	-
	Total Indels	15 (17)	4	21 (23)	4	8	4
	Indels in O_L	2	1	2	1	2	2
	Indels in N_[>=4]	11	2	16	3	5	2
Read pair data	Total aligned pairs	747,583	236,629	381,669	289,841	1,091,157	543,069
	Pairs with extended read distance (F---R)	80	39	33	97	47	14
	Pairs with R-F orientation	10,827	42	2,518	84	1,993	13
	Normalized (F---R)	80	123	65	250	32	28
	Normalized (R-F)	10,827	133	4,932	217	1,993	26
BLAST data	Reads with F-R oriented segments	47	40	32	31	-	-
	Reads with R-F oriented segments	3,307	35	767	16	-	-
	Normalized (F-R)	47	115	61	81	-	-
	Normalized (R-F)	3,307	100	1,475	42	-	-