Table 1.
Changes in echocardiographic parameters in control and PVC groups. Data are expressed as Mean ± SD.
| Control Group (n=6) | PVC Group (n=7) | Control vs. PVC | |||||
|---|---|---|---|---|---|---|---|
| Baseline | 12-weeks | Delta (95% CI) | Baseline | 12-weeks | Delta (95% CI) | P value | |
| LVEF (%) | 61 ± 6 | 60.7 ± 4 | 1.08 (-3,5) | 59.7 ± 2 | 39.7 ± 5 | -19.21 (-29.3,-9.1) | <0.0001 |
| FS (%) | 31.5 ± 2 | 32 ± 5 | 0.5 (-8.6,9.6) | 33 ± 3 | 18.3 ± 5 | -14.7 (-26,-3.4) | 0.0004 |
| LVEDD (mm) | 33.9 ± 5 | 34.8 ± 4 | 0.9 (-6.4,8.2) | 35.8 ± 3 | 40.2 ± 2 | 4.5 (-3,12) | 0.11 |
| LVESD (mm) | 23.1 ± 3 | 23.7 ± 4 | 0.6 (-3.6,4.8) | 24 ± 2 | 33.3 ± 3 | 9.3 (2.5,16.1) | 0.0002 |
| PW (mm) | 7.8 ± 1.1 | 8.3 ± 0.8 | 0.5 (-1.1,2.1) | 8.7 ± 0.5 | 8.7 ± 0.8 | 0 (-2,2) | 0.33 |
| SW (mm) | 8 ± 0.6 | 7.8 ± 1 | -0.2 (-2.5,2.1) | 8.7 ± 1.1 | 8.7 ± 0.8 | 0 (-1.1,1.1) | 0.72 |
| MR (grade 0-3+) | 0.5 ± 0 | 0.6 ± 0.2 | 0.1 (-0.3,0.5) | 0.5 ± 0 | 1.29 ± 0.7 | 0.8 (-0.6,2) | 0.03 |
| LA size (mm) | 26.7 ± 3 | 26.2 ± 3 | -0.6 (-5,4) | 29 ± 3 | 28.7 ± 2 | -0.3 (-6.4,5.9) | 0.86 |
| LA Area (cm2) | 5.7 ± 2 | 5.7 ± 1 | -0.05 (-1.6,1.5) | 6.6 ± 2 | 6.9 ± 1 | 0.2 (-2,2.4) | 0.65 |
| E/A ratio | 1.7 ± 0.2 | 1.6 ± 0.1 | -0.1 (-0.6,0.3) | 1.6 ± 0.2 | 1.3 ± 0.3 | -0.3 (-1,0.4) | 0.23 |
| E/E’ ratio | 4.2 ± 0.8 | 3.8 ± 0.8 | -0.4 (-3,2) | 3.8 ± 0.6 | 4.3 ± 0.6 | 0.4 (-1,2) | 0.19 |
| SD QRS-to-contraction | 4.4 ± 5 | 7.3 ± 7 | 3 (-10,16) | 4.7 ± 2 | 17.6 ±11 | 13 (-9,35) | 0.2 |
P value determined using a two-group independent t-test comparing the individual change score (delta) at 12 weeks between groups. CI, confidence interval; FS, Fractional shortening; LVEDD, LV end-diastolic dimension; LVESD, LV end-systolic dimension; PW, posterior wall thickness; SW, septal wall thickness; MR, mitral regurgitation (semi-quantitative, graded from 0 to 3+); SD QRS-to-contraction, standard deviation of the timing of local contractility in reference to the QRS initiation.