Table 2.
Odds ratios (ORs) and 95% confidence intervals (CIs) for history of selected chronic diseases according to FABP2 genotypes.
| Diseases | Genotype | Medical history | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Own | Family | Both | ||||||||
| Yes/No | OR | 95% CI | Yes/No | OR | 95% CI | Yes/No | OR | 95% CI | ||
| Myocardial infarction | AA | 51/777 | 1.00 | — | 358/470 | 1.00 | — | 27/801 | 1.00 | — |
| AT | 51/509 | 1.55 | 1.02–2.35 | 262/298 | 1.14 | 0.92–1.42 | 35/525 | 2.04 | 1.20–3.46 | |
| TT | 8/96 | 1.33 | 0.60–2.98 | 43/61 | 0.94 | 0.62–1.43 | 4/100 | 1.30 | 0.44–3.87 | |
| AT + TT | 59/605 | 1.51 | 1.01–2.27 | 305/359 | 1.11 | 0.90–1.36 | 39/625 | 1.93 | 1.15–3.23 | |
| P = 0.089 | P = 0.595 | P = 0.051 | ||||||||
|
| ||||||||||
| Stroke | AA | 41/787 | 1.00 | — | 258/570 | 1.00 | — | 13/815 | 1.00 | — |
| AT | 30/530 | 1.11 | 0.67–1.84 | 158/402 | 0.86 | 0.68–1.09 | 8/552 | — | — | |
| TT | 3/101 | 0.65 | 0.19–2.20 | 28/76 | 0.85 | 0.54–1.36 | 0/104 | — | — | |
| AT + TT | 33/631 | 1.05 | 0.64–1.70 | 186/478 | 0.86 | 0.68–1.08 | 8/656 | 0.80 | 0.32–1.97 | |
| P = 0.869 | P = 0.220 | P = 0.406 | ||||||||
|
| ||||||||||
| Diabetes | AA | 118/710 | 1.00 | — | 298/530 | 1.00 | — | 75/753 | 1.00 | — |
| AT | 76/484 | 0.94 | 0.68–1.31 | 234/326 | 1.32 | 1.06–1.65 | 44/516 | 0.88 | 0.59–1.32 | |
| TT | 10/94 | 0.66 | 0.32–1.35 | 41/63 | 1.26 | 0.82–1.93 | 4/100 | 0.46 | 0.16–1.30 | |
| AT + TT | 86/578 | 0.90 | 0.66–1.24 | 275/389 | 1.31 | 1.06–1.63 | 48/616 | 0.82 | 0.55–1.21 | |
| P = 0.335 | P = 0.029 | P = 0.168 | ||||||||
|
| ||||||||||
| Gallbladder disease | AA | 112/716 | 1.00 | — | 148/680 | 1.00 | — | 30/798 | 1.00 | — |
| AT | 81/479 | 1.05 | 0.76–1.44 | 118/442 | 1.20 | 0.91–1.59 | 21/539 | 0.93 | 0.52–1.68 | |
| TT | 10/94 | 0.74 | 0.37–1.49 | 14/90 | 0.73 | 0.40–1.33 | 2/102 | 0.56 | 0.13–2.43 | |
| AT + TT | 91/573 | 1.00 | 0.73–1.36 | 132/532 | 1.13 | 0.86–1.47 | 23/641 | 0.88 | 0.50–1.56 | |
| P = 0.710 | P = 0.876 | P = 0.512 | ||||||||
ORs were adjusted for age, sex, race, educational levels, cigarette smoking (pack-years), alcohol intake, body mass index, energy-adjusted dietary saturated fat, cholesterol, fiber and total calcium intakes, and family size. P values for a linear trend for the number of T-alleles.