Figure 8.

Schematic diagram showing how HP1 might influence cohesion at telomeres. (A) HP1 could act as a bridge in telomeric heterochromatin by binding to the heterochromatin mark H3K9Me3 via its CD and to TIN2-SA1 cohesin via its CSD. (B) HP1 associates with telomeres in S phase to aid in establishment of cohesion. Once cohesion is established, chromosome ends from both sisters could undergo coordinated processing, including C-strand resection, telomerase-dependent elongation, and C-strand synthesis.