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. 2011 Sep 18;2011:535241. doi: 10.4061/2011/535241

Figure 3.

Figure 3

A model for the regulation of fibroblasts by KLF5 during cardiac hypertrophy. The transcription factor KLF5 controls Igf1 and Pdgfa expression in cardiac fibroblasts. IGF-1 is a major cardiotrophic factor secreted from fibroblasts, and PDGF-A is primarily involved in mediating the migration and proliferation of fibroblasts.