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. 2011 Sep 18;2011:789323. doi: 10.1155/2011/789323

Figure 3.

Figure 3

Concentration of glutathione species and their ratio in plasma from the WHV-induced HCC woodchuck model (μM). The reduced form (GSH), the oxidized form (GSSG) of glutathione and their ratio were measured in processed plasma samples of healthy woodchucks (WHV−/HCC−), WHV-infected woodchucks (WHV+/HCC−), and WHV-induced HCC animals (WHV+/HCC+, before and 8 hours after tumor ablation). Levels of GSH were lower in the WHV+/HCC+ group when compared to the WHV−/HCC− and WHV+/HCC− groups. In contrast, levels of GSSG were higher in WHV+/HCC+ when compared to WHV−/HCC− and WHV+/HCC−. The GSH/GSSG ratio presented a ~12-fold decrease in plasma from WHV+/HCC+ animals when compared to controls. Levels of GSH increased significantly after tumor ablation in the WHV+/HCC+ animals. *P < 0.05, one-sided independent t-test; † P < 0.05, one-sided paired t-test.