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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Nat Neurosci. 2011 Jul 10;14(8):1033–1038. doi: 10.1038/nn.2862

Figure 4.

Figure 4

Normal DA reuptake and supersensitivity for cocaine in autoDrd2KO mice. (a) Representative electrically evoked (one pulse, arrows) DA signals before and after cocaine application. (b) Decay time constants (τ) of DA signal in the absence or presence of DAT blockers cocaine (COC) or methylphenidate (MPH) measured in autoDrd2KO (n = 14) and Drd2loxP/loxP mice (n = 11) (*P < 0.01). Error bars represent s.e.m. (c) Differential locomotor response to cocaine over 30 min (two-way ANOVA treatment: F2,39 = 88.91, #P < 0.001; genotype: F1,39 = 34.23, **P < 0.001; genotype × treatment interaction: F2,39 = 7.22, P < 0.05, post hoc Fisher analysis). (d) Mean s min−1 + s.e.m. spent on the drug-paired floor before and after 4 d of place preference conditioning using 5 mg per kg cocaine in Drd2loxP/loxP (n = 4) and autoDrd2KO mice (n = 4) (repeated-measures ANOVA conditioning: F1,6 = 93.05, ##P < 0.001; repeated-measures ANOVA genotype: F1,6 = 0.76, P = 0.42). (e) A tenfold lower dose of cocaine (0.5 mg per kg) induced place preference in autoDrd2KO mice (n = 6), but not in Drd2loxP/loxP mice (n = 6) (repeated-measures ANOVA genotype: F1,10 = 13.18, ***P < 0.05). Dashed lines indicate 50% of the test time (30 s). Error bars represent s.e.m.