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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Nat Neurosci. 2011 Jul 10;14(8):1033–1038. doi: 10.1038/nn.2862

Figure 5.

Figure 5

AutoDrd2KO mice displayed supramaximal DA release during train stimulation. (a) DA release in dorsal striatum evoked by trains of 30 pulses delivered at 10 Hz and 10-min intervals (pulse duration of 0.6 ms, biphasic, amplitude of 600 μA). Top, time course of DA concentration changes with insets and color plots as described in Figure 2a. (b) Effect of sulpiride on train-evoked DA release. Each figure represents average concentration-time plots for eight Drd2loxP/loxP and nine autoDrd2KO mice. (c) Horizontal locomotor activity recorded over 30 min in mice receiving saline, 0.1 or 0.6 mg per kg (intraperitoneal) of haloperidol (two-way ANOVA drug: F2,17 = 21.71, *P < 0.001 compared with saline). Error bars represent s.e.m.