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Schematic Overview of Nodal and Cripto-1 Signaling Pathways. A) Canonical Nodal signaling using Cripto-1 as a co-receptor. Nodal can also activate this pathway, albeit less efficiently, independently of Cripto-1. B) Cripto-1 Nodal-independent signaling via binding with Glypican-1 and activating src/Ras/raf/PI3K downstream signaling. C) Possible signaling of Cripto-1 through binding to beta-integrins and signaling via FAK-dependent signaling pathway.
