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. Author manuscript; available in PMC: 2011 Sep 19.
Published in final edited form as: Breast Dis. 2008;29:91–103. doi: 10.3233/bd-2008-29110

Fig. 4.

Fig. 4

Effects of Cripto-1 Transgene Expression in the Mouse Mammary Gland. A) Overexpression of human Cripto-1 in MMTV-CR-1 transgenic mice is associated with increased lateral side branching of mammary ducts and increased incidence of mammary papillary adenocarcinoma in multiparous mice. B) Overexpression of Cripto-1 in WAP-Cripto-1 transgenic mice is associated with delayed lobuloalveolar development and increased incidence of mammary gland tumors with variable histotypes including multiple areas of squamous metaplasia.