Table 1.
Tissue expression of maspin, promoter methylation status, and changes in expression resulting from neoplastic alteration
| Tissue | Cell type | Promoter status | Subcellular site | Neoplastic alteration | Ref. |
|---|---|---|---|---|---|
| Breast | Epithelial | Hypomethylated | Cytoplasmic | Methylation/↓ | (3, 11) |
| Breast | Adipocytes | Hypomethylated* | Cytoplasmic | Methylation/↓* | Khalkhali-Ellis† |
| Breast | Endothelial | Hypomethylated* | Cytoplasmic | Methylation/↓* | Khalkhali-Ellis† |
| Prostate | Epithelial | Hypomethylated | Cytoplasmic | Methylation/↓ | (3) |
| Skin | Keratinocytes | Hypomethylated | Cytoplasmic | Methylation/↓ | (15, 48) |
| Skin | Melanocytes | Hypermethylated | Cytoplasmic? | Hypomethylation/↑ | (49) |
| Gall Bladder | Epithelial | Methylated? | ND‡ | Hypomethylation/↑ | (44) |
| Biliary tract | Hypermethylated | ND‡ | Hypomethylation/↑ | (50) | |
| Thyroid | Epithelial | Methylated | ND‡ | Hypomethylation/↑ | (13, 51) |
| Pancreas | Epithelial | Methylated | Nuclear? | Hypomethylation/↑ | (52, 53) |
| Ovary | Epithelial | Methylated | Nuclear? | Hypomethylation/↑ | (11) |
| Lung | Epithelial§ | Methylated | Hypomethylation/↓ | (54) | |
| Larynx | Cytoplasmic | ↑ | (55) | ||
| Bladder | Methylated | ND‡ | Hypomethylation/↑ | (23) | |
| Stomach | Epithelial | ND‡ | ↑ | (29) | |
| Colon | Epithelial? | Hypomethylated | Cytoplasmic|| | Hypermethylation/↑ | (14) |
| Hair follicle | Hypomethylated* | Cytoplasmic | Methylation/↓* | (15), Khalkhali-Ellis† | |
| Sebaceous gland | Hypomethylated* | Cytoplasmic | Methylation/↓* | (15), Khalkhali-Ellis† | |
| Cornea | Endothelial | (29) | |||
| Cornea | Stromal | Cytoplasmic/nuclear | (29) | ||
| Cornea | Epithelial |
NOTE: In addition to the tissues listed in this table, maspin has been detected in small and large intestine, testes, tongue, thymus, vagina (25), and placenta (56), and in the absence of further information, they have not been included in the table.
The promoter status of maspin in these tissues is not determined, the author is proposing that their promoter status is hypomethylated, and neoplastic transformation will be associated with methylation, resulting in decreased maspin expression.
Unpublished observation.
Lack of maspin expression.
Cell type specific expression, positive maspin expression in basal cells of the bronchial surface epithelium and myoepithelium of the gland and negative expression in alveolar spaces.
Nuclear staining was observed in poorly differentiated tumors.