Table 4.

Molecular targets for therapy in SCC

Target category	Target	Drug example	Construction	NMSC	HNSCC	ESCC	NSCLC
Growth factor receptor	EGFR	cetuximab/panitumumab	Monoclonal Antibody		•	•	•
		erlotinib/gefitinib	tyrosine kinase inhibitors		•	•	•
	IGF-IR	IGF-IR antibody	Monoclonal Antibody		•		•
	HER3	HER3 antibody	Monoclonal Antibody		•
Signal transduction	mTOR	everolimus	mTOR inhibitor		•		•
	MET	SU11274/PF-02341066	Small molecule		•		•
	Raf/VEGFR	Sorafenib	Small molecule		•		•
	Ras	reovirus	Virus		•[249]
	MEK1/2	AZD6244	Small molecule		•[250]
Angiogenesis	VEGF	bevacizumab	Monoclonal Antibody		•		•
	Raf/VEGFR	Sorafenib	Small molecule		•		•
Cell cycle	CCND1	Flavopiridol	Kinase inhibitor		•	•
Protein degradation	Cox-2	Celecoxib/Meloxicam	Kinase inhibitor	•a		•	•
	Histone deacetylases	vorinostat	HDAC inhibitors				•
Mitosis	Polo-like kinases	Bl 2536	PLK1 inhibitor				•[251]
	Aurora Kinase A/B	Aurora Kinase inhibitor	serine/threonine kinases inhibitor		•[252]
Inducers of apoptosis	APO2	AMG655/conatumumab	Monoclonal Antibody		•[253]		•[254]
Cell adhesion molecules	CD44v6	CD44v6 antibody	Monoclonal Antibody		•[230, 255]

^aDiclofence