Table 2. Clinical Characteristics of 6,123 Subjects with Atrial Fibrillation in Derivation Cohort Followed For 21,923 Person-years on Warfarin, Comparing Subjects Who Sustained Major Hemorrhage vs. Subjects without Major Hemorrhage.

Clinical characteristic	Subjects with Major Hemorrhage N=307	Subjects without Major Hemorrhage N=5816	Hazard Ratio (95% CI)	P value
	% person-years
Age
≥ 65 years	91.5	84.3	3.3 (2.1-5.0)	<0.001
≥ 70 years	79.7	72.1	2.7 (2.0-3.7)	<0.001
≥ 75 years	61.7	53.1	2.5 (2.0-3.2)	<0.001
Female	37.4	42.0	1.0 (0.8-1.2)	0.81
Non-white race	13.8	13.4	1.2 (0.9-1.6)	0.20
Any diagnosis of cancer	18.0	15.1	1.7 (1.3-2.2)	<0.001
Prior stroke	17.4	12.4	1.4 (1.1-1.9)	0.01
Diagnosed hypertension	64.7	61.9	1.5 (1.2-1.9)	<0.001
Diabetes mellitus	22.1	20.5	1.3 (1.0-1.7)	0.03
Recent myocardial infarction	0.5	0.4	0.2 (0.0-1.2)	0.08
Prior intracranial hemorrhage	0.9	0.5	0.9 (0.2-3.6)	0.89
Prior gastrointestinal hemorrhage	12.1	6.8	2.1 (1.5-2.9)	<0.001
Prior other hemorrhage	2.9	3.1	1.3 (0.7-2.3)	0.48
Prior hematuria	10.3	5.0	2.8 (1.9-3.9)	<0.001
Any prior hemorrhage diagnosis (all-cause)	24.1	14.5	2.2 (1.7-2.8)	<0.001
Any prior hemorrhage diagnosis
> 90 days prior	21.9	13.4	3.4 (2.6-4.3)	<0.001
Within 90 days	2.2	1.0	0.3 (0.1-0.7)	0.008
Diagnosed peptic ulcer disease	5.7	4.6	1.4 (0.9-2.2)	0.11
Diagnosed cirrhosis	1.2	0.5	2.6 (1.1-6.1)	0.03
History of hepatitis	1.3	1.0	1.3 (0.4-4.1)	0.61
Prior hospital discharge diagnosis of mechanical fall	6.5	5.3	2.2 (1.5-3.2)	<0.001
Diagnosed neuropsychiatric disease	3.3	4.3	1.2 (0.7-2.0)	0.51
On clopidogrel or ticlopidine	0.9	1.0	0.5 (0.2-1.3)	0.14
Anemia	18.8	12.1	4.2 (3.4-5.3)	<0.001
Platelet count < 90,000	0.6	0.5	0.5 (0.1-3.3)	0.45
Serum creatinine
> 2.0 mg/dL	4.0	2.0	4.8 (3.4-6.6)	<0.001
> 1.5 mg/dL	9.5	5.1	3.0 (2.2-3.9)	<0.001
> 1.2 mg/dL	18.0	10.5	1.8 (1.4-2.3)	<0.001
eGFR < 30 mL/min	5.9	2.7	4.3 (3.2-5.8)	<0.001
On dialysis	0.6	0.4	2.4 (1.0-5.5)	0.05
Hemoglobin A1c > 7.0	4.1	4.3	0.9 (0.5-1.6)	0.68