Table 4. Observed Major Bleeding Rates by Risk Score and Risk Category from each Cohort.
| Derivation Cohort | Validation Cohort | Combined Cohort | ||||
|---|---|---|---|---|---|---|
| Risk Score, points* | Events/Person -years | Events per 100 person-years | Events/Person -years | Events per 100 person-years | Events/Person -years | Events per 100 person-years |
| 0 | 12/3415 | 0.35 | 9/1879 | 0.48 | 21/5294 | 0.40 |
| 1 | 26/4925 | 0.53 | 14/2395 | 0.58 | 40/7320 | 0.55 |
| 2 | 40/3757 | 1.06 | 14/1806 | 0.78 | 54/5563 | 0.97 |
| 3 | 53/5998 | 0.88 | 38/2990 | 1.27 | 91/8988 | 1.01 |
| 4 | 44/1623 | 2.71 | 18/746 | 2.41 | 62/2369 | 2.62 |
| 5 | 42/663 | 6.34 | 13/311 | 4.18 | 55/973 | 5.65 |
| 6 | 53/1089 | 4.87 | 31/607 | 5.11 | 84/1696 | 4.95 |
| 7 | 17/285 | 5.97 | 5/141 | 3.56 | 22/426 | 5.17 |
| 8 | 2/45 | 4.43 | 4/17 | 23.11 | 6/62 | 9.61 |
| 9 | 14/102 | 13.78 | 6/59 | 10.13 | 20/161 | 12.43 |
| 10 | 4/23 | 17.74 | 2/12 | 16.34 | 6/35 | 17.25 |
|
| ||||||
| Risk Category, points* | ||||||
|
| ||||||
| Low (0–3) | 131/18094 | 0.72 | 75/9071 | 0.83 | 206/27166 | 0.76 |
| Intermediate (4) | 44/1623 | 2.71 | 18/746 | 2.41 | 62/2369 | 2.62 |
| High (5–10) | 132/2205 | 5.99 | 61/1147 | 5.32 | 193/3353 | 5.76 |
|
| ||||||
| Overall | 307/21923 | 1.40 | 154/10965 | 1.40 | 461/32888 | 1.40 |
*
3 points for anemia, severe renal disease [eGFR<30 or on dialysis]; 2 points for age ≥ 75; 1 point for prior bleeding, hypertension