Table 5. Comparison of Risk Stratification Capacity (% cohort person-years), Annualized Major Hemorrhage Rate, c-index, and Net Reclassification Improvement across Hemorrhage Risk Schemes.
| Risk Scheme | Low Risk | Intermediate Risk | High Risk | c-index (95% CI) for 3-category scores* | c-index (95% CI) for continuous scores† | Net Reclassification Improvement‡ | |||
|---|---|---|---|---|---|---|---|---|---|
| % pyrs | Rate | % pyrs | Rate | % pyrs | Rate | ||||
| ATRIA risk score | 82.6 | 0.76 | 7.2 | 2.62 | 10.2 | 5.76 | 0.69 (0.66-0.71) | 0.74 (0.72-0.76) | Referent |
| Outpatient Bleeding Index | 10.1 | 0.39 | 83.0 | 1.31 | 6.9 | 3.96 | 0.59 (0.58-0.61) | 0.68 (0.65-0.70) | 50.5% |
| Kuijer et al. | 7.2 | 0.42 | 77.7 | 1.40 | 15.1 | 1.89 | 0.56 (0.55-0.58) | 0.57 (0.54-0.59) | 56.6% |
| Kearon et al. | 58.2 | 0.61 | 38.7 | 2.27 | 3.1 | 5.53 | 0.67 (0.65-0.69) | 0.69 (0.67-0.71) | 27.7% |
| HEMORR2HAGES | 65.9 | 0.72 | 29.0 | 2.49 | 5.1 | 3.96 | 0.67 (0.65-0.70) | 0.71 (0.69-0.73) | 28.9% |
| Shireman et al. | 78.6 | 0.87 | 20.3 | 3.18 | 1.0 | 6.72 | 0.64 (0.61-0.66) | 0.70 (0.68-0.73) | 33.4% |
| RIETE risk scheme | 37.6 | 0.56 | 62.0 | 1.86 | 0.4 | 10.20 | 0.63 (0.61-0.66) | 0.68 (0.65-0.70) | 44.8% |
*
c-index calculated when risk schemes were separated into 3-categories (low, intermediate, high)
†
c-index calculated when risk schemes were in a continuous format
‡
Net reclassification improvement calculated using the method by Pencina et al(14).