Table 5.
Allele frequencies of polymorphisms in eNOS (27 bp repeat, intron 4), and (786 T/C) and iNOS (22 G/A)-encoding genes in patients with lumbar disc herniation (LDH) and controls
| Gene (%) | Allele frequency | LDH (n = 50) | Controls (n = 129) | Pearson χ2 | Odds ratio (95% CI) | p |
|---|---|---|---|---|---|---|
| NOS3 (27 bp, intron 4) | 4 | 10/100 (0.1) | 34/258 (0.14) | 0.68 | 0.73 (0.32–1.62) | 0.41 |
| 5 | 90/100 (0.9) | 222/258 (0.86) | ||||
| 6 | 0/100 (0) | 2/258 (0.0) | ||||
| NOS (−786 T/C) | C | 36/87 (0.41) | 145/258 (0.66) | 4.1 | 0.6 (0.35–1.01) | 0.042* |
| T | 47/87 (0.59) | 113/258 (0.44) | ||||
| NOS2 (exon 22) | A | 35/100 (0.35) | 101/258 (0.39) | 0.53 | 0.84 (0.5 –1.39) | 0.47 |
| G | 65/100 (0.65) | 157/258 (0.61) |
* p calculated by the Mantel–Haenszel test