Figure 1.

Toll-like receptor signaling is essential for PGN-induced uveitis. MyD88 KO mice or WT controls were administered an i.v.t. injection of 5 μg PGN or saline, and ocular inflammation was assessed by intravital microscopy 6 hours later. The number of rolling (A), sticking (B), and infiltrating (C) leukocytes within the iris was quantified. Values are mean ± SE (n = 10–14 mice per group). *P < 0.05 saline vs. PGN within a genotype; ψP < 0.05 KO vs. WT mice treated with PGN.