Figure 3.

NOD2 deficiency results in exacerbated histopathlogy during PGN-triggered uveitis. NOD2 KO or WT controls were administered an i.v.t. injection of 5 μg PGN or saline, and ocular inflammation was assessed histologically at 6 and 24 hours. The number of leukocytes within the anterior and posterior segments were quantified (A, B); values are mean ± SE (n = 5 mice per group); *P < 0.05 KO vs. WT mice treated with PGN. (C, D) Representative photos taken at 400× of WT and NOD2 KO mice injected with PGN and collected 6 hours later; (E, F) images of NOD2 KO eyes at 24 hours post-PGN treatment at 400× and 1000×, respectively.