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. 2011 Jun 30;52(7):4703–4709. doi: 10.1167/iovs.10-7077

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Figure 7. — Genetic manipulation of tumor necrosis factor levels in eyes of Mertk^nmf12 mutants. Fundus photographs of P45 Mertk^nmf12/Mertk^nmf12; Tnfabc^+/+ (A) and Mertk^nmf12/Mertk^nmf12; Tnfabc^−/− (B) mice are presented. Note the pan-retinal patches in the latter. Histologic sections are of central (C) and peripheral (D) retinas of a 1-month-old Mertk^nmf12/Mertk^nmf12; Tnfabc^+/+ retina and central (E) and peripheral (F) retinas of an age-matched Mertk^nmf12/Mertk^nmf12; Tnfabc^−/− mouse. The thickness of the ONL is similar between Mertk^nmf12/Mertk^nmf12; Tnfabc^+/+ and Mertk^nmf12/Mertk^nmf12; Tnfabc^−/− mice (arrows). Central (G) and peripheral (H) retinas of a 3-month-old Mertk^nmf12/Mertk^nmf12; Tnfabc^+/+ retina and central (I) and peripheral (J) retinas of an age-matched Mertk^nmf12/Mertk^nmf12; Tnfabc^−/− retina are presented. Although the ONL of Mertk^nmf12/Mertk^nmf12; Tnfabc^+/+ retinas remains relatively intact (G, H, arrows), extensive thinning of the ONL is evident in the central and peripheral retina (I, J, arrows, respectively) of the Mertk^nmf12/Mertk^nmf12; Tnfabc^−/− mice. Scale bar, 50 μm (C–J).