Table 3.

Sensitivity and Specificity with 95% CI for Various Glaucoma Screening Test Parameters Based on Three Different Definitions of Glaucoma in the Participants in the LALES^*

Screening Test Parameters	Basis of Glaucoma Diagnosis
	Optic Nerve (n = 270) Sensitivity (95% CI)/Specificity (95% CI)	Visual Field (n = 231) Sensitivity (95% CI)/Specificity (95% CI)	Optic Nerve and Visual Field (n = 216) Sensitivity (95% CI)/Specificity (95% CI)
Vertical C/D ratio, ≥0.8	0.57 (0.52–0.63)/0.98 (0.979–0.986)	0.58 (0.51–0.64)/0.98 (0.973–0.981)	0.60 (0.54–0.67)/0.98 (0.975–0.982)
HVF GHT	0.76 (0.71–0.81)/0.72 (0.71–0.73)	0.90 (0.86–0.94)/0.72 (0.71–0.74)	0.90 (0.86–0.94)/0.71 (0.71–0.72)
HVF MD, <5%	0.78 (0.74–0.83)/0.65 (0.64–0.66)	0.89 (0.85–0.93)/0.64 (0.63–0.65)	0.88 (0.84–0.92)/0.64 (0.63–0.65)
HVF expert reading	0.64 (0.59–0.70)/0.89 (0.88–0.90)	0.80 (0.75–0.85)/0.89 (0.88–0.90)	0.80 (0.75–0.85)/0.89 (0.89–0.90)
HVF PSD, ≥5%	0.66 (0.60–0.71)/0.78 (0.77–0.79)	0.77 (0.72–0.82)/0.78 (0.77–0.79)	.076 (0.71–0.82)/0.78 (0.77–0.79)
FDT perimetry	0.59 (0.53–0.65)/0.79 (0.78–0.80)	0.68 (0.62–0.75)/0.80 (0.79–0.81)	0.67 (0.61–0.73)/0.79 (0.78–0.80)
IOP, ≥21 mm Hg	0.21 (0.16–0.26)/0.97 (0.97–0.97)	0.23 (0.18–0.29)/0.97 (0.97–0.98)	0.24 (0.18–0.30)/0.97 (0.97–0.97)
CCT, ≤504 μm	0.14 (0.10–0.18)/0.91 (0.90–0.92)	0.18 (0.13–0.23)/0.91 (0.90–0.92)	0.16 (0.11–0.21)/0.91 (0.90–0.92)
HVF false negatives, ≥33%	0.04 (0.02–0.06)/0.98 (0.98–0.99)	0.05 (0.02–0.08)/0.98 (0.98–0.99)	0.05 (0.02–0.08)/0.98 (0.98–0.99)

n = 6082.

^*Sensitivity is the proportion of participants having glaucoma according to the glaucoma diagnostic criteria who test positive by the given screening parameter. Specificity is the proportion of participants not having glaucoma according to the glaucoma diagnostic criteria who test negative by the given screening parameter.