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HT reduces NV tufts formation and accelerates retina revascularization in OIR. OIR mice were treated with hyperoxia (75% or 40% oxygen; HT) or were maintained in room air (OIR) from P14 to P20. (A) Retinas from OIR mice treated with 75% oxygen were whole flatmounted at P20. Representative images are shown. Original magnification, ×5. (B) NV areas (red) and (C) avascular areas (yellow) were quantified (n = 6–9 retinas from 6–9 mice). *P < 0.05 compared with OIR.
