Table 4.

Effects of MSO and Pressure-Loading on Retinal Damage

Condition (n)	NFLT vs. RT (%) [P]	GC Count (n) [P]	NDS (n) [P]
10 mm Hg (7)	2.2 ± 0.8 [–]	0.1 ± 0.1 [–]	0.1 ± 0.1 [–]
10 mm Hg + 1 mM MSO (6)	2.7 ± 0.7 [0.152]	0.2 ± 0.1 [0.150]	0.3 ± 0.3 [0.061]
10 mm Hg + 2 mM MSO (5)	5.4 ± 1.0 [<0.0001]*	8.1 ± 0.2 [<0.0001]*	0.3 ± 0.3 [0.061]
35 mm Hg (5)	1.5 ± 0.6 [–]	0.1 ± 0.1 [–]	0.1 ± 0.1 [–]
35 mm Hg + 1 mM MSO (6)	5.1 ± 1.6 [<0.0001]*	12.1 ± 2.3 [<0.0001]*	0.7 ± 0.3 [<0.0001]*
35 mm Hg + 2 mM MSO (6)	5.9 ± 2.4 [<0.0001]*	20.8 ± 1.1 [<0.0001]*	3.6 ± 0.5 [<0.0001]*
75 mm Hg (7)	7.2 ± 2.6 [–]	1.8 ± 1.0 [–]	0.9 ± 0.4 [–]
75 mm Hg + 1 mM MSO (6)	10.2 ± 3.6 [0.047]*	16.2 ± 4.7 [<0.0001]*	0.9 ± 0.4 [0.009]*
75 mm Hg + 2 mM MSO (6)	11.6 ± 2.8 [0.002]*	26.0 ± 5.1 [<0.0001]*	3.6 ± 0.5 [<0.0001]*

Data are the mean ± SD. The density of damaged ganglion cells was counted per 100 μm of the retina. P values were calculated versus control (10 mm Hg) by Student's t-test.

^*Statistically significant at P < 0.05.