Table 5.
Effect of TFB-TBOA and MSO Combined on Retinal Features
Condition (n) | NFLT vs. RT (%) [P] | GC Count (n) [P] | NDS (n) [P] |
---|---|---|---|
10 mm Hg (6) | 1.8 ± 0.6 [–] | 0.1 ± 0.1 [–] | 0.2 ± 0.1 [–] |
20 nM TBOA + 1 mM MSO (7) | 12.5 ± 4.4 [<0.0001]* | 18.1 ± 4.7 [<0.0001]* | 3.0 ± 1.1 [<0.0001]* |
20 nM TBOA + 2 mM MSO (6) | 14.2 ± 1.6 [<0.0001]* | 22.5 ± 2.7 [<0.0001]* | 3.2 ± 0.4 [<0.0001]* |
40 nM TBOA + 1 mM MSO (5) | 13.2 ± 0.7 [<0.0001]* | 24.1 ± 4.1 [<0.0001]* | 3.7 ± 0.5 [<0.0001]* |
40 nM TBOA + 2 mM MSO (6) | 12.2 ± 0.6 [<0.0001]* | 26.5 ± 2.3 [<0.0001]* | 3.8 ± 0.4 [<0.0001]* |
Data are the mean ± SD. The density of damaged ganglion cells was counted per 100 μm of the retina. P values were calculated versus control (10 mm Hg) by Student's t-test.
Statistically significant at P < 0.05.