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Responses to ivt LPS are less sensitive to tolerance from ip LPS pretreatment. All mice received an ip injection of either 25 μg LPS or saline. After 72 hours, they were challenged with either an ip 100 μg LPS injection or an ivt 250 ng LPS injection. Cytokine levels in eye tissue and plasma were measured by ELISA at 4 hours after challenge. Values are the mean ± SEM; *P < 0.05 compared with saline treatment; n = 10–12 mice/treatment. Results are representative of two experiments.
