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IP LPS desensitizes the eye to cellular infiltration in response to ivt LPS. Mice were administered ip injections of 25 μg LPS or saline and, at the same time, ivt injections of either 250 ng LPS or saline. All four possible combinations were tested. The intraocular inflammation at 6 hours after injection was assessed by intravital microscopy. Values are the mean ± SEM; *P < 0.05 compared with saline treatment; n = 8 to 14 mice/treatment. Results are representative of two experiments.
