Figure 2.

Longitudinal sequence of visual function in a CRB1-RD patient spanning 11 years. (A) Kinetic perimetry results in P7 at three ages. (B) Dark-adapted (top) and light-adapted (bottom) static threshold perimetry results displayed as grayscale maps of rod and cone sensitivity loss. Scale and labels as in Figure 1. (C) Dark-adapted two-color sensitivity profiles across the central 60° in P7 at the three ages. Top: sensitivity to the 500-nm stimulus compared with normal for rod-mediated sensitivity to this stimulus (shaded band). Bottom: sensitivity to the 650-nm stimulus compared with cone-mediated sensitivity to the same stimulus at the cone plateau (dashed lines). Top graph: photoreceptor mediation at loci with function: M, mixed rod (500 nm) and cone (650 nm) function; C, cone-mediated.