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Opa1 and Fis1 protein levels are increased in neural retinas of cbs+/− mice. Representative Western blots of Opa1 (Mr ∼80–100 kDa), Fis1 (Mr ∼17 kDa), MFN1 (Mr ∼84 kDa), MFN2 (Mr ∼86 kDa), and DRP1 (Mr ∼82 kDa) showing increased levels of Opa1 (1.91 ± 0.26 of wild-type, P < 0.019) and Fis1 (2.26 ± 0.05 of wild-type, P < 0.0001) in retinas of cbs+/− mice. Levels of Mfn1, Mfn2, and Drp1 remained unchanged compared with wild-type.
