Figure 8.

Phenotypic analysis of mRDef transgenic mice by light microscopy. Histologic sections of (A) wild-type retina at 2 months, (B–D) mRDef^Rpgr−/− at 2 to 8 months, and (E) mRDef^{Rpgr wt} at 8 months. (G–I) mRDef^Rpgr−/− mice were crossed with mROrf^Rpgr−/− mice, and the retinal phenotypes of 4-month-old single- and double-transgenic littermates were assessed by light microscopy at 4 months of age. RPE, retinal pigment epithelium; ONL, outer nuclear layer; INL, inner nuclear layer; GC, ganglion cell layer.