Figure 2.

Amino acid sequence conservation around residues affected by novel missense mutations in BBS1, BBS5, BBS6, BBS8, BBS9, and BBS10 identified in this study. Asterisk: position of the missense mutation. The sequences of BBS proteins or predicted translation products from several species have been compared and aligned. The relevant amino acids are in bold, and they are underlined when different from Homo sapiens reference; other identities are represented by a gray background. Homo, H. sapiens; Mus, Mus musculus; Rattus, Rattus norvegicus; Xenopus, Xenopus (silurana) tropicalis; Danio, Danio rerio; Bos, Bos taurus; Pongo, Pongo abelii; Gallus, gallus; Pan, Pan troglodytes; Equus, Equus caballus.