Table 1.

Physicochemical Properties of the β-Blockers

Solubility data were obtained from the website: http://www.drugbank.ca (provided by the Department of Biological Sciences, University of Alberta, Calgary, Alberta, Canada). Molecular weight and pKa values were obtained from SciFinder Scholar 2007 (provided by Chemical Abstracts Science, The American Chemical Society, Columbus, OH; http://www.cas.org). Octanol-PBS (pH 7.4) distribution coefficients (log D) of the drug forms listed in the Materials and Methods section were previously determined by us at 37°C using the shake flask method by our group.⁶ Partition coefficients (log P) were obtained from the literature.¹⁵