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Demonstration of human SLC5A8-mediated OTC transport in the Xenopus laevis oocyte expression system. (A) SLC5A8 cRNA-injected oocytes were perifused with 1 mM nicotinate in the presence of NaCl (+Na+) or NMDG chloride (-Na+). Currents were monitored by the two-microelectrode voltage-clamp technique. (B) SLC5A8 cRNA-injected oocytes were perifused with 1 mM OTC in the presence of NaCl (+Na+) or NMDG chloride (-Na+).
