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Inhibition of human SLC5A8 (SMCT1)-mediated nicotinate transport by OTC in Xenopus laevis oocytes. Na+-dependent uptake of [14C]-nicotinate (30 μM) was measured in water-injected (control) oocytes and in SLC5A8 (SMCT1)-expressing oocytes in the presence or absence of OTC (1 mM).
