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. 2011 Jul 27;52(8):5749–5757. doi: 10.1167/iovs.10-6825

Figure 6.

Figure 6.

Dose-dependent blockade of human SLC5A8-mediated OTC transport by ibuprofen. (A) OTC (100 μM)-induced currents were monitored in SLC5A8 cRNA-injected oocytes in the presence of NaCl and increasing concentrations of ibuprofen. (B) The percent inhibition of OTC-induced currents by each concentration of ibuprofen was calculated from the above experiment, and the data were used to determine the concentration of ibuprofen needed to cause 50% maximal inhibition by fitting the Michaelis–Menten equation to the data. Inset: Eadie–Hofstee plot. I, percent inhibition; S, ibuprofen concentration in μM.