Ud
|
Deleterious mutation rate in nonmutators |
λUd
|
Deleterious mutation rate in mutators |
x |
Negative log fitness of an individual (larger x corresponds to lower fitness) |
ρ(x) |
Distribution of fitness effects of deleterious mutations |
R(k) |
Laplace transform of ρ(x) |
M |
Difference between mutator and nonmutator deleterious mutation rates |
γ |
Mutation rate from nonmutators to mutators |
fn(x,t) |
Distribution of fitnesses of nonmutators at time t
|
fm(x,t) |
Distribution of fitnesses of mutators at time t
|
F{n,m}(k,t) |
Laplace transform of fn(x,t) or fm(x,t) |
σ |
Effect of a typical deleterious mutation |
α |
Defined as M/σ |
δn,δm
|
Average deleterious load of nonmutators or mutators respectively |
pm
|
Fraction of mutators in the total population |
τ |
Average lifetime of a single mutator lineage |
η |
Backmutation rate from mutators to nonmutators |
Ub,λUb
|
Beneficial mutation rate in nonmutators or mutators respectively |
N |
Population size |
sb
|
Fitness advantage provided by a beneficial mutation |
s |
Fitness advantage of a beneficial mutant relative to population mean fitness |