Table 4.
Number and proportions of patients who used specific antihypertensive drugs and adjusted odds ratios for change
| Intervention | Controls | Intergroup comparison | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 2001 | 2003 | Adjusted* OR (95% CI) | p-value | 2001 | 2003 | Adjusted* OR (95% CI) | p-value | Adjusted** OR (95% CI) | p-value | |
| n (%) | n (%) | |||||||||
| Hypertension, N | 2250 | 2969 | 5504 | 6717 | ||||||
| Diuretics | 886 (39.4) | 1143 (38.5) | 0.97 (0.86, 1.08) | 0.56 | 2207 (40.1) | 2575 (38.3) | 0.92 (0.85, 0.99) | 0.02 | 1.06 (0.92, 1.21) | 0.44 |
| Beta-blockers | 982 (43.6) | 1312 (44.2) | 1.04 (0.93, 1.16) | 0.50 | 2335 (42.4) | 2890 (43.0) | 1.03 (0.96, 1.12) | 0.35 | 1.01 (0.88, 1.15) | 0.93 |
| CCBs | 560 (24.9) | 747 (25.2) | 1.04 (0.92, 1.18) | 0.55 | 1349 (24.3) | 1682 (25.0) | 1.04 (0.95, 1.13) | 0.43 | 0.99 (0.84, 1.14) | 1.00 |
| RAAS | 738 (32.8) | 1108 (37.3) | 1.19 (1.06, 1.34) | 0.004 | 1966 (35.7) | 2724 (40.6) | 1.24 (1.15, 1.34) | <0.0001 | 0.96 (0.83, 1.10) | 0.56 |
| CHD, N | 320 | 440 | 950 | 1148 | ||||||
| Diuretics | 71 (22.2) | 98 (22.3) | 1.02 (0.71, 1.46) | 0.92 | 171 (18.0) | 229 (19.9) | 1.05 (0.84, 1.33) | 0.67 | 0.98 (0.64, 1.50) | 0.92 |
| Beta-blockers | 235 (73.4) | 350 (79.5) | 1.39 (0.99, 1.96) | 0.06 | 762 (80.2) | 932 (81.2) | 1.13 (0.90, 1.41) | 0.29 | 1.25 (0.83, 1.88) | 0.29 |
| CCBs | 103 (32.2) | 113 (25.7) | 0.75 (0.54, 1.03) | 0.08 | 203 (21.4) | 261 (22.7) | 1.06 (0.86, 1.31) | 0.59 | 0.70 (0.48, 1.03) | 0.07 |
| RAAS | 43 (13.4) | 86 (19.5) | 1.57 (1.05, 2.34) | 0.03 | 156 (16.4) | 218 (19.0) | 1.16 (0.92, 1.46) | 0.20 | 1.34 (0.85, 2.12) | 0.21 |
| Diabetes, N | 302 | 456 | 612 | 828 | ||||||
| Diuretics | 115 (38.1) | 184 (40.4) | 1.10 (0.81, 1.49) | 0.54 | 278 (45.4) | 365 (44.1) | 0.93 (0.75, 1.15) | 0.49 | 1.19 (0.82, 1.72) | 0.37 |
| Beta-blockers | 127 (42.1) | 216 (47.4) | 1.24 (0.93, 1.67) | 0.15 | 275 (44.9) | 379 (45.8) | 1.03 (0.83, 1.28) | 0.76 | 1.21 (0.84, 1.74) | 0.31 |
| CCBs | 91 (30.1) | 137 (30.0) | 0.99 (0.72, 1.37) | 0.96 | 148 (24.2) | 223 (26.9) | 1.13 (0.88, 1.45) | 0.33 | 0.88 (0.59, 1.32) | 0.54 |
| RAAS | 159 (52.6) | 249 (54.6) | 1.08 (0.80, 1.45) | 0.64 | 284 (46.4) | 427 (51.6) | 1.27 (1.02, 1.57) | 0.03 | 0.85 (0.59, 1.23) | 0.39 |
Prescription data was drawn from the national Prescription Register during a three-month period in 2001 and 2003.
Abbreviations: CCBs, calcium channel blockers; RAAS, agents acting on renin-angiotensin-aldosterone system; CHD, coronary heart disease; OR, Odds ratio; CI, confidence interval.
*Within-group analysis: Logistic regression, random effects model (physician as a random effect). Adjusted for patient's age and patient's sex.
**Intergroup analysis: Logistic regression, random effects model (physician as a random effect). A product term between time (after versus before) and group (intervention versus control) was added in the model. Adjusted for patient's age and patient's sex.