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. 2011 Sep 5;4:149–168. doi: 10.2147/OTT.S21553

Table S1.

IC50 values after incubation with drugs from the Approved Oncology Drug Set II

Drug name (NSC numbera) IC50 (μmol/L)
Cell line
SEM B1 KOPN8 MOLT-3 TIB-202
Microtubule stabilizersb
Docetaxel (628503) <1.00 × 10−2 2.78 × 10−4 <1.00 × 10−2 <1.00 × 10−2 5.88 × 10−2
Paclitaxel (125973) <1.00 × 10−2 8.04 × 10−2 ± 3.49 × 10−2 <1.00 × 10−2 1.00 × 101 1.06 × 10−1
Microtubule destabilizers
Vinblastine (49842) 1.00 × 10−2 9.93 × 10−4 <1.00 × 10−2 8.51 × 10−1 8.79 × 10−3
Vincristine (67574) <1.00 × 10−2 4.42 × 10−2 <1.00 × 10−2 1.00 × 101 4.02 × 10−2
DNA damaging agents
Altretamine (13875) >1.00 × 101 >1.00 × 101 >1.00 × 101 >1.00 × 101 >1.00 × 101
Bleomycin (125066) <1.00 × 10−2 2.92 × 100 ± 2.23 × 100 1.08 × 10−1 8.42 × 100 1.07 × 100 ± 1.84 × 10−1
Busulfan (750) >1.00 × 101 >1.00 × 101 >5.00 × 100 6.36 × 100 >5.00 × 100
Carboplatin (241240) >1.00 × 101 7.73 × 100 5.14 × 100 6.97 × 100 7.64 × 100
Carmustine (409962) >1.00 × 101 >1.00 × 101 >5.00 × 100 >1.00 × 101 >5.00 × 100
Chlorambucil (3088) 7.29 × 100 6.41 × 100 3.38 × 100 5.56 × 100 4.47 × 100
Cisplatin (119875) >1.00 × 101 >1.00 × 101 >5.00 × 100 >1.00 × 101 >5.00 × 100
Cyclophosphamide (26271) >1.00 × 101 >1.00 × 101 >5.00 × 100 >1.00 × 101 >5.00 × 100
Dacarbazine (45388) >1.00 × 101 >1.00 × 101 >1.00 × 101 >1.00 × 101 >1.00 × 101
Estramustine (702294) >1.00 × 101 >1.00 × 101 >1.00 × 101 >1.00 × 101 >1.00 × 101
Ifosfamide (109724) >1.00 × 101 >1.00 × 101 >5.00 × 100 >1.00 × 101 >5.00 × 100
Lomustine (79037) 9.35 × 100 8.32 × 100 >5.00 × 100 >1.00 × 101 >5.00 × 100
Melphalan (8806) 5.80 × 100 4.08 × 100 4.25 × 10−1 1.03 × 100 2.20 × 100
Mitomycin C (26980) 5.04 × 10−2 3.71 × 10−1 ± 5.56 × 10−2 5.94 × 10−2 ± 4.38 × 10−2 2.21 × 10−2 8.55 × 10−2 ± 6.02 × 10−2
Nitrogen mustard (762) 8.83 × 10−1 9.58 × 10−1 1.99 × 100 >1.00 × 101 3.42 × 100
Oxaliplatin (266046) 5.67 × 100 3.68 × 100 3.09 × 10−1 9.69 × 10−1 6.20 × 100
Pipobroman (25154) 4.32 × 100 2.63 × 100 3.89 × 10−1 6.35 × 100 4.34 × 100
Procarbazine (77213) >1.00 × 101 >1.00 × 101 >5.00 × 100 >1.00 × 101 >5.00 × 100
Streptozocin (85998) >1.00 × 101 >1.00 × 101 >5.00 × 100 >1.00 × 101 >5.00 × 100
Temozolomide (362856) 9.12 × 100 >1.00 × 101 >5.00 × 100 >1.00 × 101 >5.00 × 100
Thiotepa (6396) 3.78 × 100 6.38 × 100 1.96 × 100 3.01 × 100 5.00 × 100
Triethylenemelamine (9706) 4.81 × 10−1 3.97 × 10−1 1.97 × 10−1 2.60 × 10−1 4.47 × 10−1
Uracil mustard (34462) 4.85 × 100 3.65 × 100 2.22 × 100 9.66 × 100 2.70 × 100
DNA intercalating agents
Dactinomycin (3053) <1.00 × 10−2 <1.00 × 10−2 <1.00 × 10−10 <1.00 × 10−2 <1.00 × 10−5
Daunorubicin (82151) <1.00 × 10−2 9.45 × 10−3 ± 1.92 × 10−3 <5.00 × 10−3 <1.00 × 10−2 1.08 × 10−2
Doxorubicin (123127) <1.00 × 10−2 1.20 × 10−1 ± 1.41 × 10−1 <1.00 × 10−2 7.84 × 100 5.85 × 10−2
Mitoxantrone (279836) <1.00 × 10−2 <1.00 × 10−2 <1.00 × 10−2 3.42 × 10−1 <1.00 × 10−2
Nucleic acid synthesis inhibitors
Capecitabine (712807) >1.00 × 101 >1.00 × 101 >1.00 × 101 >1.00 × 101 >1.00 × 101
Clofarabine (606869) 2.58 × 10−2 <1.00 × 10−2 8.70 × 10−3 >1.00 × 101 <1.00 × 10−2
Floxuridine (27640) >1.00 × 101 8.48 × 100 >5.00 × 100 >1.00 × 101 >5.00 × 100
Fludarabine (312887) 8.87 × 10−2 9.09 × 10−2 7.05 × 10−2 >1.00 × 101 7.31 × 10−2
Fluorouracil (19893) >1.00 × 101 >1.00 × 101 >5.00 × 100 7.11 × 100 >5.00 × 100
Gemcitabine (613327) <1.00 × 10−2 2.57 × 10−2 ± 1.03 × 10−2 <5.00 × 10−3 <1.00 × 10−2 5.65 × 10−2 ± 7.28 × 10−2
Hydroxyurea (32065) >1.00 × 101 >1.00 × 101 >5.00 × 100 >1.00 × 101 >5.00 × 100
Mercaptopurine (755) >1.00 × 101 >1.00 × 101 >5.00 × 100 >1.00 × 101 >5.00 × 100
Nelarabine (686673) >1.00 × 101 >1.00 × 101 >1.00 × 101 1.23 × 100 >1.00 × 101
Pemetrexed (698037) >1.00 × 101 6.71 × 10−1 1.58 × 10−1 5.67 × 10−1 1.79 × 10−1
Pentostatin (218321) >1.00 × 101 >1.00 × 101 >5.00 × 100 >1.00 × 101 >5.00 × 100
Thioguanine (752) 9.38 × 10−1 8.77 × 100 4.50 × 100 7.05 × 100 5.20 × 100
Aromatase inhibitors
Anastrozole (719344) 2.08 × 100 >1.00 × 101 >1.00 × 101 >1.00 × 101 >1.00 × 101
Exemestane (713563) 2.08 × 100 >1.00 × 101 8.89 × 100 >1.00 × 101 >1.00 × 101
Letrozole (719345) >1.00 × 101 >1.00 × 101 >1.00 × 101 >1.00 × 101 >1.00 × 101
DNA methyltransferase inhibitors
Azacitidine (102816) 1.30 × 100 5.07 × 100 8.36 × 10−1 6.21 × 100 5.20 × 100
Histone deacetylase inhibitors
Vorinostat (701852) >1.00 × 101 3.82 × 100 4.16 × 10−1 5.67 × 10−1 4.30 × 100
mTOR inhibitors
Everolimus (733504) <1.00 × 10−2 8.34 × 10−1 <1.00 × 10−2 >1.00 × 101 <1.00 × 10−2
Rapamycin (226080) <1.00 × 10−2 8.04 × 10−3 <1.00 × 10−2 <1.00 × 10−2 7.05 × 100 ± 4.17 × 100
Proteasome inhibitors
Bortezomib (681239) <1.00 × 10−2 3.97 × 10−3 <1.00 × 10−2 >1.00 × 101 5.71 × 10−3
Tyrosine kinase inhibitors
Dasatinib (732517) 4.05 × 100 <1.00 × 10−6 7.48 × 10−3 >1.00 × 101 <1.00 × 10−6
Imatinib (743414) 7.68 × 100 2.06 × 10−1 ± 1.34 × 10−2 >1.00 × 101 >1.00 × 101 2.70 × 10−1 ± 3.07 × 10−1
Lapatinib (745750) 4.73 × 100 5.70 × 100 5.20 × 100 >1.00 × 101 7.42 × 100
Nilotinib (747599) >1.00 × 101 <1.00 × 10−2 >1.00 × 101 >1.00 × 101 <1.00 × 10−2
Sorafenib (747971) 1.54 × 100 5.66 × 100 3.86 × 100 9.63 × 100 5.95 × 100
Sunitinib (750690) 1.35 × 10−1 5.36 × 100 3.30 × 100 >1.00 × 101 3.29 × 100
Topoisomerase poisons
Etoposide (141540) 9.28 × 10−2 7.10 × 10−1 ± 5.81 × 10−1 1.97 × 10−2 1.07 × 10−1 4.56 × 10−1 ± 3.12 × 10−1
Irinotecan (616348) 3.40 × 100 2.29 × 100 1.69 × 100 3.92 × 100 2.53 × 100
Teniposide (122819) 9.28 × 10−3 2.98 × 10−2 ± 3.09 × 10−2 1.80 × 10−4 1.17 × 10−2 4.91 × 10−2 ± 3.08 × 10−2
Topotecan (609699) <1.00 × 10−2 2.76 × 10−2 ± 3.85 × 10−2 <1.00 × 10−2 <1.00 × 10−2 4.53 × 10−2
EGFR inhibitors
Erlotinib (718781) 1.00 × 100 2.98 × 100 5.82 × 100 5.70 × 100 6.68 × 100
Gefitinib (715055) 4.89 × 100 5.16 × 100 5.08 × 100 >1.00 × 101 9.28 × 100
Estrogen receptor modulators
Fulvestrant (719276) >1.00 × 101 >1.00 × 101 7.64 × 100 >1.00 × 101 >1.00 × 101
Raloxifene (747974) 4.44 × 100 >1.00 × 101 8.30 × 100 >1.00 × 101 >1.00 × 101
Tamoxifen (180973) >1.00 × 101 6.45 × 100 2.70 × 100 1.00 × 101 >5.00 × 100
Immunomodulatory agents
Imiquimod (369100) >1.00 × 101 >1.00 × 101 2.90 × 100 >1.00 × 101 >1.00 × 101
Lenalidomide (747972) >1.00 × 101 >1.00 × 101 >1.00 × 101 1.00 × 101 >1.00 × 101
Thalidomide (66847) >1.00 × 101 >1.00 × 101 >5.00 × 100 >1.00 × 101 >5.00 × 100
Photo-activated agents
Aminolevulinic acid (18509) >1.00 × 101 >1.00 × 101 >1.00 × 101 >1.00 × 101 >1.00 × 101
Methoxsalen (45923) >1.00 × 101 >1.00 × 101 >5.00 × 100 >1.00 × 101 >5.00 × 100
Protective adjuvant drugs
Allopurinol (1390) >1.00 × 101 >1.00 × 101 >5.00 × 100 >1.00 × 101 >5.00 × 100
Amifostine (296961) >1.00 × 101 >1.00 × 101 >1.00 × 101 >1.00 × 101 >1.00 × 101
Dexrazoxone (169780) >1.00 × 101 >1.00 × 101 >5.00 × 100 >1.00 × 101 >5.00 × 100
Zoledronic acid (721517) >1.00 × 101 >1.00 × 101 >1.00 × 101 >1.00 × 101 >1.00 × 101
Miscellaneous drugs
Acrichine (14229) 6.40 × 100 4.63 × 100 7.22 × 10−1 4.07 × 100 4.50 × 100
Arsenic trioxide (92859) >1.00 × 101 >1.00 × 101 1.69 × 10−1 >1.00 × 101 >1.00 × 101
Celecoxib (719627) >1.00 × 101 >1.00 × 101 >1.00 × 101 >1.00 × 101 >1.00 × 101
Megestrol acetate (71423) >1.00 × 101 >1.00 × 101 >5.00 × 100 >1.00 × 101 >5.00 × 100
Mitotane (38721) >1.00 × 101 >1.00 × 101 >5.00 × 100 >1.00 × 101 >5.00 × 100
Tretinoin (122758) >1.00 × 101 >1.00 × 101 >5.00 × 100 >1.00 × 101 >5.00 × 100

Notes:

a

Compound identification number in the National Cancer Institute/National Institutes of Health Developmental Therapeutics Program database;

b

Some drugs may have more than one mechanism of action.

Abbreviation: IC50, half maximal inhibitory concentration.