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. 2011 Aug 15;18(1):56. doi: 10.1186/1423-0127-18-56

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Copyright ©2011 Tsao et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Soluble Notch ligands activated Notch signaling and amplified LPS-induced inflammatory responses. (A) Soluble Jagged1 (sJag1; 1 μg/ml) augmented LPS-induced Hes5 and Hey2 mRNA expression in macrophages. sDll1 (B) and sDll4 (C) also had a similar effect. (D) sJag1, sDll1, and sDll4, especially sDll1 (all 1 μg/ml), significantly enhanced LPS-induced NICD formation. (), fold change as compared to basal level. sDll1 significantly amplified LPS-induced IL-1β (E) and IL-6 (F) secretion in macrophages. *, P < 0.05.