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. 2011 Sep 19;6(9):e24156. doi: 10.1371/journal.pone.0024156

Figure 4. Analysis of DNA methylation in 16.5 dpc and day 6 male germ cells from Dnmt3L+/+ and Dnmt3L−/− mice demonstrating a wide-spread loss of methylation across chromosome 9.

Figure 4

A) Average percent methylation across chromosome 9 at 16.5 dpc and day 6 in Dnmt3L+/+ (n = 70, n = 72) and Dnmt3L−/− (n = 24, n = 48) germ cells. Error bars indicate SEM across the chromosome. Significance was determined using the Mann-Whitney test of individual measurements across the chromosome (* indicates p<0.001). B) Comparison of Dnmt3L+/+ (n = 3) and Dnmt3L−/− (n = 1) germ cells at 16.5 dpc demonstrating a drastic loss of DNA methylation at most sites examined. Error bars indicate SEM. C) Bisulfite sequencing at sites 1, 12, 17, 43 and 48 in Dnmt3L+/+ and Dnmt3L−/− germ cells at 16.5 dpc and day 6.